Follitropin
Bemfola, Gonal-f, Ovaleap, Pergoveris (follitropin) is a protein pharmaceutical. Follitropin was first approved as Gonal-f on 1995-10-20. It has been approved in Europe to treat anovulation, assisted reproductive techniques, female infertility, and hypogonadism. The pharmaceutical is active against follicle-stimulating hormone receptor.
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FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| follistim aq | Biologic Licensing Application | 2025-02-03 |
| gonal-f | Biologic Licensing Application | 2024-07-15 |
| gonal-f rff | Biologic Licensing Application | 2023-11-20 |
| gonal-f rff redi-ject | Biologic Licensing Application | 2025-04-03 |
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696 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infertility | D007246 | EFO_0000545 | — | 27 | 34 | 72 | 94 | 142 | 355 |
| Female infertility | D007247 | EFO_0008560 | N97 | 11 | 7 | 18 | 12 | 36 | 79 |
| Polycystic ovary syndrome | D011085 | EFO_0000660 | E28.2 | 3 | 3 | 8 | 9 | 32 | 54 |
| Fertilization in vitro | D005307 | — | — | 1 | 3 | 3 | 20 | 9 | 35 |
| Syndrome | D013577 | — | — | 2 | 3 | 3 | 5 | 23 | 35 |
| Ovulation induction | D010062 | — | — | 3 | 8 | 6 | 8 | 7 | 31 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 4 | 1 | 3 | 7 | 15 |
| Healthy volunteers/patients | — | — | — | 7 | 1 | 1 | 1 | 6 | 15 |
| Hypogonadism | D007006 | — | E23.0 | — | 1 | 2 | 6 | 5 | 14 |
| Fertility | D005298 | — | — | 2 | — | 2 | 4 | 4 | 12 |
Show 35 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Primary ovarian insufficiency | D016649 | EFO_0004266 | E28.3 | 6 | 6 | 1 | — | 22 | 31 |
| Premature menopause | D008594 | — | E28.31 | 5 | 5 | 1 | — | 19 | 26 |
| Endometriosis | D004715 | EFO_0001065 | N80 | 2 | 1 | 1 | — | 8 | 11 |
| Pituitary diseases | D010900 | — | E23.7 | 1 | 1 | 2 | — | 5 | 9 |
| Azoospermia | D053713 | EFO_0000279 | N46.0 | — | — | 1 | — | 3 | 4 |
| Thyroid neoplasms | D013964 | EFO_0003841 | — | — | 1 | 2 | — | — | 3 |
| Thyroid diseases | D013959 | — | E00-E07 | — | 1 | 2 | — | — | 3 |
| Prostatic neoplasms | D011471 | — | C61 | 1 | 1 | 1 | — | 1 | 3 |
| Ovarian pregnancy | D065172 | — | O00.2 | — | — | 1 | — | 1 | 2 |
| Oligospermia | D009845 | — | N46.1 | — | — | 1 | — | — | 1 |
Show 6 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Premature birth | D047928 | EFO_0003917 | O60 | 4 | 4 | — | — | 8 | 13 |
| Menopause | D008593 | EFO_0003922 | N95 | 2 | 2 | — | — | 3 | 6 |
| Lymphoma | D008223 | — | C85.9 | 1 | 2 | — | — | 1 | 3 |
| Male breast neoplasms | D018567 | — | — | 1 | 1 | — | — | 1 | 2 |
| Leukemia | D007938 | — | C95 | 1 | 1 | — | — | 1 | 2 |
| Papillary thyroid cancer | D000077273 | — | — | — | 1 | — | — | — | 1 |
| Follicular adenocarcinoma | D018263 | — | — | — | 1 | — | — | — | 1 |
| Infections | D007239 | EFO_0000544 | — | 1 | 1 | — | — | — | 1 |
| Leiomyoma | D007889 | — | D25 | 1 | 1 | — | — | — | 1 |
| Ectopic pregnancy | D011271 | — | O00 | 1 | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pharmacokinetics | D010599 | — | — | 2 | — | — | — | — | 2 |
| Therapeutic equivalency | D013810 | — | — | 2 | — | — | — | — | 2 |
| Delayed puberty | D011628 | — | E30.0 | 1 | — | — | — | 1 | 2 |
| Area under curve | D019540 | — | — | 1 | — | — | — | — | 1 |
| Absorption | D000042 | — | — | 1 | — | — | — | — | 1 |
| Precocious puberty | D011629 | — | E22.8 | 1 | — | — | — | — | 1 |
| Asymptomatic diseases | D058070 | — | — | 1 | — | — | — | — | 1 |
| Perimenopause | D047648 | — | — | 1 | — | — | — | — | 1 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 1 | — | — | — | — | 1 |
| Ovarian epithelial carcinoma | D000077216 | — | — | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | — | U07.1 | — | — | — | — | 5 | 5 |
| Muscular dystrophies | D009136 | EFO_0000757 | G71.0 | — | — | — | — | 5 | 5 |
| Ovarian diseases | D010049 | — | — | — | — | — | — | 4 | 4 |
| Endocrine system diseases | D004700 | EFO_0001379 | E34.9 | — | — | — | — | 4 | 4 |
| Turner syndrome | D014424 | Orphanet_881 | Q96 | — | — | — | — | 3 | 3 |
| Gonadal dysgenesis | D006059 | — | — | — | — | — | — | 3 | 3 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | — | — | — | 3 | 3 |
| Ovarian cysts | D010048 | — | N83.1 | — | — | — | — | 3 | 3 |
| Hypopituitarism | D007018 | EFO_0001380 | E23.0 | — | — | — | — | 3 | 3 |
| Facioscapulohumeral muscular dystrophy | D020391 | EFO_0000491 | G71.02 | — | — | — | — | 3 | 3 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Follitropin |
| INN | follitropin alfa |
| Description | Gonadotropin preparations are drugs that mimic the physiological effects of gonadotropins, used therapeutically mainly as fertility medication for ovarian hyperstimulation and ovulation induction. For example, the so-called menotropins consist of LH and FSH extracted from human urine from menopausal women. There are also recombinant variants.
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| Classification | Protein |
| Drug class | tricyclic compounds; atropine derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
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4,058 adverse events reported
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